Antimicrobial Drug Interaction Essay
Antimicrobial Drug Interaction Essay
Erythromycin is an antimicrobial agent that inhibits protein synthesis. The antimicrobial agent binds to the 23 subunits of the rRNA molecule, which eventually blocks the exit of the protein peptide. The antimicrobial agent acts against the gram-positive bacteria, which means that it inhibits protein production (Nguyen et al., 2018). It also causes ribosome stalling. On the other hand, the bacteria mutate from time to time as they try to evade the antimicrobial agent.
The common side effects of erythromycin include stomach pain, diarrhea, and loss of appetite. The drug may cause serious adverse reactions such as vomiting and nausea and so patients should be monitored for QT prolongation and pseudomembranous colitis, as well as food intolerance (Shekharappa et al., 2018). The medication is contraindicated to patients with known drug allergies. Erythromycin interacts with terfenadine, pimozide, and astemizole. A clinical trial conducted by Karbassi et al. (2022) confirms the bacteriostatic efficacy of erythromycin, which results in its wide use in treating staphylococcus infections.
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Ethnic, cultural, and genetic considerations are important in the prescription of erythromycin. The incidences of antimicrobial resistance continue to escalate at a worrying rate. The incidence is attributed to poor adherence to medication prescriptions. Some people stop taking the antimicrobials immediately the symptoms alleviate. The cultural practice is a major drawback to the effectiveness of erythromycin and other antimicrobials in treating bacterial infections (Bryant et al., 2020). Furthermore, as part of cultural consideration, the healthcare providers should analyze the financial stability of the patients. Most people from low-income families prefer generic drugs. In terms of genetics, some people are allergic to antimicrobial agents and this limits the possibility of the medication being prescribed to them. Understanding the patient’s history and cultural values is important in developing their treatment plan.
References
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Bryant, A. E., Bayer, C. R., Aldape, M. J., McIndoo, E., & Stevens, D. L. (2020). Emerging erythromycin and clindamycin resistance in Group A streptococci: Efficacy of linezolid and tedizolid in experimental necrotizing infection. Journal of Global Antimicrobial Resistance, 22, 601-607. https://doi.org/10.1016/j.jgar.2020.04.032
Karbassi, E., Amiri-Ardekani, E., Farsinezhad, A., Shahesmaeili, A., Abhari, Y., Ziaesistani, M., Pouryazdanpanah, N., Derakhshani, A., Jamshidi, F., & Tajadini, H. (2022). The efficacy of kohl (Surma) and erythromycin in treatment of blepharitis: An open-label clinical trial. Evidence-Based Complementary and Alternative Medicine, 2022, 1-6. https://doi.org/10.1155/2022/6235857
Nguyen, H. L., Pham, D. L., O’Brien, E. P., & Li, M. S. (2018). Erythromycin leads to differential protein expression through differences in electrostatic and dispersion interactions with nascent proteins. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-24344-9
Shekharappa, C. B., Bhat, S., & Chandrasekaran, A. (2018). Role of oral erythromycin for feed intolerance in neonates – A randomized controlled trial. Indian Journal of Child Health, 05(06), 413-418. https://doi.org/10.32677/ijch.2018.v05.i06.005
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Select an antimicrobial medication that inhibits bacterial protein synthesis. Share the antibacterial spectrum and hints for monitoring, side effects, and drug interactions, including interactions with CAM. Discuss ethnic, cultural, and genetic considerations that must be considered for treatment. In addition, share a clinical trial that supports the use of this agent. Include the name of the medication in the subject line so that the medications can be followed. Include references using APA format.