Tranexamic Acid Essay
Tranexamic Acid Essay
The final product of the coagulation cascade; in hemostasis, is the formation of a cross-linked fibrin clot. However, the normal physiologic mechanisms provide for endogenous fibrinolysis that counters against arterial thrombosis and its consequent events. In a setting of active bleeding, this mechanism becomes counter-productive in that, it may perpetuate hemorrhage. This forms the basis of the mechanism of action of tranexamic acid which is a potent anti-fibrinolytic drug. Its ultimate action is the prolongation of physiologic breakdown/dissolution of the already formed fibrin polymer, therefore, ameliorating the bleeding. The drug is available in both oral and parenteral formulations.
The food and drug administration (FDA) approves the use of tranexamic acid for menorrhagia and short-term prevention in individuals with hemophilia (Ferrari et al., 2022). However, its off-label use in surgery to minimize perioperative bleeding points toward its potential benefits in the management of postpartum hemorrhage. In a systemic review by Ferrari et al., (2022) to establish the effects of tranexamic acid on the prevention and treatment of primary postpartum hemorrhage, it was established that 1g of tranexamic acid was effective in preventing postpartum hemorrhage after vaginal and cesarian delivery.
ORDER A PLAGIARISM FREE-PAPER HERE
Similarly, research by Sentilhes et al. (2021) to determine the effectiveness of tranexamic acid in preventing blood loss after cesarean section demonstrated that postpartum blood loss occurred in 26.7% of women in the treatment group and 31.7% of women in the placebo group (adjusted risk ratio, 0.84; 95% confidence interval [CI], 0.75 to 0.94; P=0.003). In conclusion, tranexamic acid has a positive impact on the management of postpartum hemorrhage. The world health organization recommends its early use in the course of management to optimize outcomes
References
Ferrari, F. A., Garzon, S., Raffaelli, R., Cromi, A., Casarin, J., Ghezzi, F., Uccella, S., & Franchi, M. (2022). Tranexamic acid for the prevention and the treatment of primary postpartum hemorrhage: a systematic review. Journal of Obstetrics and Gynaecology: The Journal of the Institute of Obstetrics and Gynaecology, 1–13. https://doi.org/10.1080/01443615.2021.2013784
Struggling to meet your deadline ?
Get assistance on
Tranexamic Acid Essay
done on time by medical experts. Don’t wait – ORDER NOW!
Sentilhes, L., Sénat, M. V., Le Lous, M., Winer, N., Rozenberg, P., Kayem, G., Verspyck, E., Fuchs, F., Azria, E., Gallot, D., Korb, D., Desbrière, R., Le Ray, C., Chauleur, C., de Marcillac, F., Perrotin, F., Parant, O., Salomon, L. J., Gauchotte, E., … Groupe de Recherche en Obstétrique et Gynécologie. (2021). Tranexamic acid for the prevention of blood loss after cesarean delivery. The New England Journal of Medicine, 384(17), 1623–1634. https://doi.org/10.1056/NEJMoa2028788
ORDER A PLAGIARISM FREE-PAPER HERE
Does the use of tranexamic acid in patients at risk for post-partum hemorrhage decreases blood loss when compared to not using?