Select a viral infection. Select a medication and discuss the ethnic, cultural, or genetic differences in the uses for the treatment of a viral infection. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions. In addition, share a clinical trial that supports the use of this agent. Include the name of the medication in the subject line so that the medications can be followed. Include references in APA format.
Genital herpes is a viral infection that is sexually transmitted. It is caused by the herpes simplex virus. The virus tends to be dormant in the body after the initial infection and can be reactivated severally. Valacyclovir is an antiviral used in treating genital herpes. It is administered as valacyclovir hydrochloride which is rapidly converted to acyclovir that induces antiviral activities towards the herpes simplex virus. Furthermore, the medication is a nucleoside analog DNA polymerase inhibitor that prevents the replication of the virus in the body. The medication induces selective DNA inhibition because of its strong affinity to the thymidine kinase (Álvarez et al., 2020). The possible side effects of the valacyclovir include seizure, confusion, and kidney problems. Therefore, drug use should be limited to patients with kidney problems.
Ethnic and genetic factors affect how an individual responds to treatment. There are cases where a person may have heightened immunogenicity due to genetic factors. In such cases, the patient could respond adversely to the treatment. In terms of ethnicity and culture, some people do not believe in medication intake because of perception or religious beliefs.
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A clinical trial conducted by Kazsoki et al. (2022) indicated that valacyclovir is effective for managing genital herpes infection. The findings from the study are supported by Kłysik et al. (2020). Therefore, it is recommendable when patients with genital herpes are initiated on the valacyclovir treatment.The drug has also been shown to be effective among women in pregnancy. The recommended dosing based on the clinical trial was 1g once daily dose. The dose can be reduced to 500mg OD depending on the patient’s clinical presentation.
References
Álvarez, D. M., Castillo, E., Duarte, L. F., Arriagada, J., Corrales, N., Farías, M. A., Henríquez, A., Agurto-Muñoz, C., & González, P. A. (2020). Current antivirals and novel botanical molecules interfering with herpes simplex virus infection. Frontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.00139
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Select a viral infection. Select a medication and discuss the ethnic, cultural, or genetic differences in the uses for the treatment of a viral infection. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions. In addition, share a clinical trial that supports the use of this agent. Include the name of the medication in the subject line so that the medications can be followed. Include references in APA format.
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Kazsoki, A., Palcsó, B., Alpár, A., Snoeck, R., Andrei, G., & Zelkó, R. (2022). Formulation of acyclovir (core)-dexpanthenol (sheath) nanofibrous patches for the treatment of herpes labialis. International Journal of Pharmaceutics, 611, 121354. https://doi.org/10.1016/j.ijpharm.2021.121354
Kłysik, K., Pietraszek, A., Karewicz, A., & Nowakowska, M. (2020). Acyclovir in the treatment of herpes viruses – A review. Current Medicinal Chemistry, 27(24), 4118-4137. https://doi.org/10.2174/0929867325666180309105519
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Select a viral infection. Select a medication and discuss the ethnic, cultural, or genetic differences in the uses for the treatment of a viral infection. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions. In addition, share a clinical trial that supports the use of this agent. Include the name of the medication in the subject line so that the medications can be followed. Include references in APA format.