Pharmacokinetics and Pharmacodynamics of Benzodiazepines in the Treatment of Generalized Anxiety Disorder Essay
Pharmacokinetics and Pharmacodynamics of Benzodiazepines in the Treatment of Generalized Anxiety Disorder Essay
Benzodiazepines are a class of medications that have been used for some time in the treatment of anxiety disorders, even though their use in this respect has been causing controversy. The implication is that there are professionals who avoid their use completely due to the problems they cause, while others still prescribe them. With respect to pharmacodynamics and pharmacokinetics, the use of Benzodiazepines has various advantages and disadvantages in treating Generalized Anxiety Disorder (Michael Van Ameringen et al., 2020).
When used in treating Generalized Anxiety Disorder, benzodiazepines have various advantages. One of the advantages is that they are well tolerated by most patients. The other advantage is that their use is considered safe when appropriately administered and used (Guina & Merrill, 2018). The next advantage is that they work quickly when administered to the patient as they are facts acting. Benzodiazepines also lower other unpleasant physiologic symptoms such as panic, insomnia, and tension.
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The use of Benzodiazepines in the treatment of Generalized Anxiety Disorder has various disadvantages. Some of them include adverse psychiatric reactions. Some of the drugs have been shown to cause memory impairment and various other cognitive defects. During the onset of their use, Benzodiazepines can also cause daytime anxiety and early morning insomnia. Seizures, anxiety, and rebound insomnia can also occur following withdrawal (Guina & Merrill, 2018). It is also important to note that inappropriate use of Benzodiazepines can lead to addiction. Indeed, this is one of the major reasons that those who are against their use point to. Even though the medications can be used in the treatment of Generalized Anxiety disorder, prolonged use is not recommended since such long-term use may be unsafe.
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References
Guina, J., & Merrill, B. (2018). Benzodiazepines II: waking up on sedatives: providing optimal care when inheriting benzodiazepine prescriptions in transfer patients. Journal of clinical medicine, 7(2), 20. https://doi.org/10.3390/jcm7020020.
Guina, J., & Merrill, B. (2018). Benzodiazepines I: upping the care on downers: the evidence of risks, benefits and alternatives. Journal of clinical medicine, 7(2), 17. https://dx.doi.org/10.3390%2Fjcm7020017
Michael Van Ameringen, M. D., Dabas, G., Sharpe, I., & Marrello, D. (2020). Pharmacotherapy for Generalized Anxiety Disorder. The American Psychiatric Association Publishing Textbook of Anxiety, Trauma, and OCD-Related Disorders, 197.
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DISCUSSION QUESTION: Pharmacokinetics and Pharmacodynamics of Benzodiazepine
In respect to its pharmacokinetics and pharmacodynamics, what are the advantages and disadvantages of the use of Benzodiazepines in the treatment of Generalized Anxiety Disorder (or GAD)?