Identify a fungal infection and, using the treatment guidelines, select a medication to treat the fungal infection. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions, including interactions with CAM. Elaborate on one drug-drug interaction and devise a plan to clinically manage the interaction. Discuss evidence and treatment guidelines to determine appropriate therapeutic options for a patient with a fungal infection. Include the name of the medication in the subject line so that the medications can be followed. Include references in APA format.
Vaginal candidiasis is a fungal infection caused by candida albican. The condition is treated using fluconazole which is given at a dose of 400mg orally. The dosing period depends on the severity of the infections. Though candida albican is a normal flora in the vagina, changes in the environment could influence an overgrowth that is infectious. Fluconazole is a fluorine-substituted that acts like other azoles. The drug interrupts the conversion of the lanosterol to ergosterol and thus inhibiting the membrane formation (Lírio et al., 2019). On the other hand, the side effects associated with the medication include headache, nausea, diarrhea, and vomiting among others. Patients using fluconazole should have their liver functioning monitored considering that prolonged use of the medication could cause severe hepatic injury. Patients with liver diseases should not be initiated on fluconazole.
Fluconazole interacts with flibanserin and erythromycin. In terms of CAM, the medication interacts with vitamin B12 and vitamin K. Also, it promotes the action of probiotics. Therefore, the prescriber must know the other medication and supplements being taken by the patient to determine whether they should be initiated on fluconazole or not.
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There is significant evidence supporting the use of fluconazole in managing vaginal candidiasis from the study by Collins et al. (2020). Though there are concerns of resistance emerging and this means that dose may be adjusted and duration increased to two weeks in case of poor response (Lírio et al., 2019). Also, the user should be limited among pregnant mothers because of the possible harmful effects such as musculoskeletal malformation (Zhu et al., 2020).
References
Collins, L. M., Moore, R., & Sobel, J. D. (2020). Prognosis and long-term outcome of women with idiopathic recurrent vulvovaginal candidiasis caused by Candida albicans. Journal of Lower Genital Tract Disease, 24(1), 48-52.doi.org//10.1097/LGT.0000000000000496
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Identify a fungal infection and, using the treatment guidelines, select a medication to treat the fungal infection. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions, including interactions with CAM. Elaborate on one drug-drug interaction and devise a plan to clinically manage the interaction. Discuss evidence and treatment guidelines to determine appropriate therapeutic options for a patient with a fungal infection. Include the name of the medication in the subject line so that the medications can be followed. Include references in APA format.
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Lírio, J., Giraldo, P. C., Amaral, R. L., Sarmento, A. C. A., Costa, A. P. F., & Gonçalves, A. K. (2019). Antifungal (oral and vaginal) therapy for recurrent vulvovaginal candidiasis: a systematic review protocol. BMJ open, 9(5), e027489.https://doi.org//10.1136/bmjopen-2018-027489corr1
Zhu, Y., Bateman, B. T., Gray, K. J., Hernandez-Diaz, S., Mogun, H., Straub, L., & Huybrechts, K. F. (2020). Oral fluconazole use in the first trimester and risk of congenital malformations: population-based cohort study. BMJ, 369.
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Identify a fungal infection and, using the treatment guidelines, select a medication to treat the fungal infection. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions, including interactions with CAM. Elaborate on one drug-drug interaction and devise a plan to clinically manage the interaction. Discuss evidence and treatment guidelines to determine appropriate therapeutic options for a patient with a fungal infection. Include the name of the medication in the subject line so that the medications can be followed. Include references in APA format.